fat and stress

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

fat and stress

Postby trisca » Mon May 20, 2013 6:15 am

I was wondering about a connection between fat and stress and if there is a known relationship between them. From personal experience I know that I have more problems when stressed and that I respond well to a low fat diet. I did a tiny bit of digging on google scholar and found that elevated oxidative stress is somehow related to relapses.

Substantial evidence indicates that stress can precipitate or worsen symptoms of inflammation in general and more specifically in multiple sclerosis (MS), a demyelinating, autoimmune disease characterized by inflammation of the central nervous system (CNS). However, the mechanism of how stress affects MS is not well understood. We reviewed publications in PubMed since 1995 and propose that neuropeptides secreted under stress, such as corticotropin releasing hormone (CRH) and neurotensin (NT), activate microglia and mast cells to release inflammatory molecules. These lead to maturation and activation of T17 autoimmune cells, disruption of the blood–brain barrier (BBB) and T cell entry into the CNS, thus promoting brain inflammation and contributing to MS pathology. Reduction of stress and inhibition of these processes by select flavonoids could provide novel therapeutic approaches.

http://www.sciencedirect.com/science/ar ... 7213000438

I'd say that that is in line with my personal experience. So I had a look to see if anyone has linked stress to fats and found some interesting associations.

Our study suggests that a four-week diet rich in either palmitic acid or linoleic acid induces an oxidative stress in the rat liver of non-diabetic rats, as shown by increased lev- els of hepatic TBARS and changes in the activity of antiox- idant enzymes. Therefore, in healthy subjects high content in a diet of both saturated (palmitic) and polyunsaturated (linoleic) fatty acids should be considered a potentially harmful factor with respect to pro- and antioxidative bal- ance in the liver. However, in diabetic rats a diet rich in linoleic acid partially prevents STZ-induced generation of peroxidation products, thus it appears to attenuate the oxidative stress in the liver. A diet rich in palmitic acid does not seem to modify diabetes-induced oxidative stress effec- tively, since it does not change the level of TBARS, despite significant diet-induced changes in antioxidant enzyme activity.


Whether PUFA diets affect inflammatory mediators in central and peripheral sites is not clear. We investigated the effect of high-fat PUFA diets on the expression of proteins involved in inflammatory pathways in hypothalamus, muscle, and liver. Male rats were fed for 2 months with either chow or high-fat diets enriched with either soy (n-6 PUFAs) or fish oil (n-3 PUFAs). The fish group had normal body weight, low serum NEFA, reduced hypothalamic levels of TNF-α, IL-6, and TRAF6, and increased levels of IL-10 receptor. In contrast, the soy group had increased body weight and hypothalamic levels of TRAF6 and NFκBp65. In muscle, the fish diet reduced TNF-α and IL-6 levels. Both PUFA diets increased muscle IL-10 levels and reduced liver TNF-α and IL-6 levels. The data showed that the high-fat soy diet induced activation of the hypothalamic NFκB inflammatory pathway, a feature predisposing to feeding and energy expenditure disturbances associated with the development of obesity. On the other hand, the high-fat fish diet improved the central and the peripheral inflammatory profile via reduction of intracellular inflammatory mediators, suggesting a protection against obesity.

Dysfunction of the blood–brain barrier (BBB) is an early pathological feature of vascular dementia and Alzheimer's disease (AD) and is triggered by inflammatory stimuli. Probucol is a lipid-lowering agent with potent anti-oxidant properties once commonly used for the treatment of cardiovascular disease. Probucol therapy was found to stabilize cognitive symptoms in elderly AD patients, whereas in amyloid transgenic mice probucol was shown to attenuate amyloidosis. However, the mechanisms underlying the effects of probucol have note been determined.
In the present study we investigated whether probucol can prevent BBB disturbances induced by chronic ingestion of proinflammatory diets enriched with either 20% (w/w) saturated fats (SFA) or 1% (w/w) cholesterol. Mice were fed the diets for 12 weeks before they were killed and BBB integrity was measured.
Mice maintained on either the SFA- or cholesterol-supplemented diets were found to have a 30- and sevenfold greater likelihood of BBB dysfunction, respectively, as determined by the parenchymal extravasation of plasma-derived immunoglobulins and endogenous lipoprotein enrichment with β-amyloid. In contrast, mice fed the SFA- or cholesterol-enriched diets that also contained 1% (w/w) probucol showed no evidence of BBB disturbance. The parenchymal expression of glial fibrillary acidic protein, a marker of cerebrovascular inflammation, was significantly greater in mice fed the SFA-enriched diet. Plasma lipid, β-amyloid and apolipoprotein B levels were not increased by feeding of the SFA- or cholesterol-enriched diets. However, mice fed the SFA- or cholesterol-enriched diets did exhibit increased plasma non-esterified fatty acid levels that were not reduced by probucol.
The data suggest that probucol prevents disturbances of BBB induced by chronic ingestion of diets enriched in SFA or cholesterol by suppressing inflammatory pathways rather than by modulating plasma lipid homeostasis.

http://onlinelibrary.wiley.com/doi/10.1 ... 12032/full

Maybe reduced fat in the diet helps counter-act the effects of neuropeptides released during stress? Is that why Swank "works"? Is that how the primrose oil supplements came about? Or sat fat enables the disruption of the bbb which allows the stress secretions access to cause havoc in the brain? Is the latitude issue from the counter-balancing effect of the sun on suppressing the immune system, and that high fish diets have the same result?

Is this something that is commonly thought? I'm a bit late to the game.
Family Member
Posts: 67
Joined: Sat Dec 08, 2012 5:24 am


Re: fat and stress

Postby Lainie » Mon May 20, 2013 11:20 am

New study shows positive stress helpful, negative stress harmful for PwMS


I like this study because it recognizes that not all stress is bad.
User avatar
Family Member
Posts: 64
Joined: Tue Feb 06, 2007 4:00 pm
Location: WI

Return to General Discussion


  • Related topics
    Last post

Who is online

Users browsing this forum: ElliotB

Contact us | Terms of Service