It is the inability to properly "metabolize" vitamin B12 due to a lack of enzymes, specifically protease and DNase 1, that I believe the evidence shows is the reason for the low vitamin B12 and resulting high homocysteine found in Alzheimer's disease and MS.
In the following study the researchers stated that there is increasing evidence for an association between Alzheimer’s disease and “nutritionally independent” cobalamin (vitamin B12) deficiency. The researchers believe this may be due to a PROTEASE inhibition, a "common factor" in Alzheimer’s disease. The lack of protease results in protein-bound cobalamin malabsorption and disrupted cobalamin metabolism.
Trypsin inhibition: a potential cause of cobalamin deficiency common to the pathogenesis of Alzheimer-type dementia and AIDS dementia complex?
McCaddon, A., B. Regland, C.F. Fear. 1995. Med Hypotheses. 45(2):200-4.
“There is increasing evidence for an association between Alzheimer-type dementia (AD) and nutritionally independent cobalamin deficiency. Furthermore, low serum cobalamin values occur in a kindred with familial Alzheimer's disease (FAD) and histopathological confirmation of AD neuropathology…This paper presents the hypothesis that protease inhibition is a common factor in AD and ADC resulting in protein-bound cobalamin malabsorption and disrupted cobalamin metabolism.”
In addition to low vitamin B12 and elevated homocysteine, there are many more disease ramifications that would result from these missing enzymes. A lack of these enzymes results in other nutrients that are not being properly metabolized as well. The question is, should you take these nutrients in supplement form if your body is unable to properly metabolize them? Is there a possibility you may see an increased risk of disease? I will be providing some more information on this.
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