Applause to you for helping out someone close to you with MS.
If you spend some time searching around the boards, you will find many alternatives that are being tested out anecdotally. When considering the aggressive course of PPMS, you should spend some time investigating statins, antibiotics, and Campath, in addition to Novantrone, Tysabri (no proof of efficacy in PPMS) and the higher dose interferons (likewise). There are hosts more; information is available in each dedicated section here.
You mentioned funding-- please be aware that many, if not all, of the MS therapeutic companies offer assistance to patients in need. For example, here is some contact information:
, Rebif (call the MSLifeLines Support Program at 1-877-447-3243), Betaseron (call the Berlex Patient Assistance Program at 1-800-948-5777), Avonex (call the Avonex Assistance Program at 1-800-456-2255), and so on.
Welcome to the site,