CNS Vasodilation - Relief by flush

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CNS Vasodilation - Relief by flush

Postby THX1138 » Tue Jan 07, 2014 2:47 pm

Between 1946 and 1959, more than 3000 patients with multiple sclerosis and other demyelinating diseases were treated with the CNS vasodilator histamine diphosphate at the Multiple Sclerosis Clinic of St. Joseph Hospital in Tacoma. Most of them improved, some quite dramatically (Jonez 1952).

http://www.overcomingmultiplesclerosis.org/Community/Forum/viewtopic.php?f=10&t=2520



and

(11) Hazel Young says:
Twenty-five years ago I was diagnosed with primary progressive MS. A year later I had all invisible signs of multiple sclerosis and I was walking with a cane. It often felt as if I were walking underwater. Going up and down stairs was almost impossible. In desperation, I began taking massive doses of vitamins. One of these was niacin.

Upon taking the niacin I would develop the “niacin flush” which would last for about twenty minutes. As I felt the blood rushing throughout my body, for that glorious twenty minutes, I would feel the MS lifting from my body. I would run up and down stairs, stairs I couldn‘t navigate five minutes before. I would grab my husband’s hand and we would walk around the block (yes, without my cane). We would put on our favourite record and dance like we hadn’t done in more than a year. Then the flush would disappear and the MS would take over my body once again.

No doctor has ever been able to explain why the niacin flush had this effect on me, but I always knew it had something to do with blood flow. As this niacin website states: “Niacin causes the capillaries in your body to get bigger…capillaries are the main way for your body to rid itself of toxins.”
http://www.mens-total-fitness.com/niacin-flush.html

When I watched Dr. Zamboni’s Liberation Treatment on television it finally felt like maybe there was a connection.
http://ms.about.com/b/2009/12/01/ccsvi-and-multiple-sclerosis.htm


THX1138
Last edited by THX1138 on Wed Jan 08, 2014 12:21 pm, edited 6 times in total.
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Re: CNS Vasodilation - Relief by flush

Postby jimmylegs » Wed Jan 08, 2014 7:00 am

more info:

personally, I considered the benefits of the transient niacin flush to be due to improved delivery of oxygen and nutrients to starved tissues. the longer term challenge would be to get systems working so that I wouldn't need the niacin. in addition to using supplemental niacin in the short term, i changed my diet to include more nutrient-dense sources of niacin (namely, animal products).

I discovered the niacin flush reaction first by accident and second in the context of the klenner protocol. I never noticed specific relief of symptoms with niacin use, especially not specific to the duration of the transient flush reaction. the klenner protocol benefits showed up suddenly on day three, unassociated with anything specific timing-wise or individual-nutrient-wise.

also, should an individual need higher doses of niacin to achieve a good flush, or they can't achieve a flush at all, omega 3 and zinc status should be considered as well: http://www.sciencedirect.com/science/ar ... 7780901255

FYI, niacin safety considerations: http://www.sciencedirect.com/science/ar ... 4906022363
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Re: CNS Vasodilation - Relief by flush

Postby centenarian100 » Wed Jan 08, 2014 7:04 pm

Interesting.

Tecfidera also produces flushing, supposedly by a similar bradykinin dependent mechanism. Has anyone experienced transient benefits while experiencing flushing as a side effect of tecfidera?
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