I have been on Rebif for about 2 years now. I didn't have any problems in the beginning, but my injection site reactions are not fun here lately. I am covered in red circles from every injection. They aren't painful. Just there. One on my arm was very itchy at first, but otherwise fine. Also, when I give myself the injection, shooting the Rebif in hurts like hell. Not the needle...the actual medication going into my body. The MS Lifelines nurses say that this is normal and it's to the point where I have to be thankful that it's working for me and weigh that against the side effects. And it IS working for me. My infant son s 19 months old and I have yet to relapse after my pregnancy. These site reactions are just awful though. I didn't used to mind giving myself the injections, but now I'm beginning to dread it. Anyone try anything that really works to help these symptoms? I've used hot and cold compresses and haven't gotten any type of relief. Not sure what else to do. Thank you!