Hi folks - first post (male, 42, symptomatic 20 yrs, EDSS 7.5, SPMS, on minocycline 20mg/day, baclofen 30mg/night, clonazepam 0.25mg/night, I'm in a manual chair). I also pee like crazy 1 out of every 3 or 4 nights. If I first pee with a full bladder (250-300mL) at 1am, say, I will have to go again 1.5 hrs later, same full bladder, then again every 1.5 hrs until I physically get up out of bed. I have peed 1.5L in one night! Driving me insane.
I drink very little during the day as a result (usually 1L or less, one coffee) and nothing after 6pm (we go to bed 9-10ish). So I[m probably dehydrated most of the time.
The first pee is the normal night-time colour (slightly dense); the rest are straw-clear, as though I've been chugging water.
I eat healthily, am slim, and have no other conditions (e.g., diabetes). My lab tests are normal. My neuro, GP, and physiatrist are stumped/unhelpful ("just use a Foley" - thanks).
Anyone else have this? Any explanations? Could it be the baclofen?