Tolerance-directed immunotherapy: Future of MS treatment?

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Tolerance-directed immunotherapy: Future of MS treatment?

Postby MSUK » Fri May 30, 2014 12:56 am

It may take some time and require overcoming certain hurdles, but the future of multiple sclerosis (MS) management may lie in delivering therapies that make immune cells tolerant of specific antigens.

These "tolerance-directed" immunotherapies could eventually provide a safe, cost-effective, and highly efficient alternative to current approaches to MS treatments that suppress the immune system and inevitably lead to patients becoming more susceptible to infections, cancer, and other disorders.

Stephan D. Miller, PhD, Judy Guggenheim Research Professor of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, elaborated on the development of these precisely targeted immunotherapies in his opening lecture at the 6th Cooperative Meeting of the Consortium of Multiple Sclerosis Centers (CMSC) and the Americas Committee for Treatment and Research In Multiple Sclerosis (ACTRIMS)....... Read More -
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Re: Tolerance-directed immunotherapy: Future of MS treatment

Postby Zac » Fri May 30, 2014 7:11 am

What about stem cells ?
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Re: Tolerance-directed immunotherapy: Future of MS treatment

Postby Leonard » Mon Jun 02, 2014 5:15 am

The immune system is normally 'tolerant' for trans-genic cells; our case is a bit special with EBV driven immune complexes which show some cross reaction.

What if MS/disability progression is not uniquely linked to the immune system 'attacking' transgenic cells? Then the tolerance directed immunotherapy won't do a whole lot. I think that is actually the case where the auto-immunity seen in MS is just collateral damage. The real cause are the free radicals jamming the mitochondria of the cells and poisoning the lipids in our brains.

see also general-discussion-f1/topic15188.html
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