MS-associated retrovirus

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MS-associated retrovirus

Postby dignan » Tue Jun 13, 2006 8:37 am

Another possible viral (retroviral) trigger?

Multiple sclerosis-associated retrovirus and optic neuritis.

Mult Scler. 2006 Jun;12(3):357-9.
Sotgiu S, Arru G, Soderstrom M, Mameli G, Serra C, Dolei A.
Institute of Clinical Neurology, University of Sassari, Viale San Pietro 10, 07100 Sassari, Italy.

One prognostic factor for early multiple sclerosis (MS) patients to develop a definite MS may be the presence of the MS-associated retrovirus (MSRV) in the cerebrospinal fluid (CSF). We designed a specific study on a cohort of optic neuritis (ON) patients to evaluate the MSRV-dependent conversion to MS relative to the prediction conferred by magnetic resonance imaging (MRI) and CSF abnormalities.

At follow-up, 33.3% MSRV+ and 0% MSRV- ON patients developed MS (P = 0.03). The prediction value is lower than that given by CSF and MRI abnormalities (42.3%). This intriguing finding is discussed in the light of the abundant discrepancies observed in the MSRV literature. ... med_DocSum
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