excellent web site

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

excellent web site

Postby jimmylegs » Fri Aug 11, 2006 9:24 pm

if anyone wants to have a look into detailed things that can cause neuropathy, here is a site which i think is really fantastic. at first (back in feb) i thought it had the best descriptor of b12 deficiency. but now (hit it on a diff search today) i realize it has fantastic information for a great range of things including neurotoxins and channel toxins. here's the path i've been on so far and i'm enthralled:

vitamin syndromes:

sample info:

Thiamine (B1) deficiency (beri-beri)
Metabolically active form
Thiamine pyrophosphate (TPP): Hydroxyl group is replaced by diphosphate ester group
TPP is a coenzyme for two types of enzymes: Cleave a C-C bond adjacent to a carbonyl group
α-Ketoacid dehydrogenases
TPP dependent enzymes also require a divalent cation, commonly Mg++
Enzyme systems
α-ketoglutarate dehydrogenase: Krebs cycle
Pyruvate dehydrogenase: Pyruvate ® Acetyl CoA
Transketolase: Pentose monophosphate shunt
Sources: Yeast, Pork, Legumes, Cereal grains, Rice (Whole grain)

Clinical features
Extraocular movement paresis
Peripheral neuropathy10
Progression: Variable; Acute (< 1 month) 50%; Chronic (> 1 year) 20%
Weakness (Legs): 50%
Sensory loss (Legs): 50%
Distribution: Symmetric; Legs > Arms
Distal > Proximal
Legs (Foot dorsiflexors) & Hands (Wrist extensors; 80%)
Sensory loss: Large & Small fiber modalities
Burning feet; Lancinating pain; Calf tenderness
Frequency: Some patients
Autonomic neuropathy: With severe disease
Orthostatic hypotension
Bladder: Flaccid
GI: Gas retention
Tendon reflexes: Reduced or Absent
Cranial nerve weakness (Occasional): Laryngeal (Hoarseness), Face & Tongue
Cerebellar degeneration
Acute: Wernicke's disease
Mental status change: Confusion; Memory loss; Agitation
Ataxia: Especially truncal
Ocular: Paresis; Nystagmus; Retinal hemorrhages
Chronic: Korsakoff's psychosis
Memory disorders
Cardiac failure (Wet beri-beri): Congestive; Tachycardia; Edema
Infantile: Acute cardiac failure
Anorexia: Weight loss
Associated or causative disorders
Malnutrition: Polished rice; HIV infection; Systemic malignancy; Anorexia nervosa
Malabsorption & repeated vomiting: Gastric resection; Pregnancy
Diet with thiaminases: Raw fish (carp)
Infantile beri-beri: Breast-feeding infants whose mothers are thiamine deficient
Transketolase activity: Whole blood or Erythrocyte
Increased RBC Transketolase activity after addition of thiamine diphosphate (TPP)
Urine thiamine excretion: 24 hour
Other lab
Serum pyruvate: High
Nerve conduction: Motor & Sensory axon loss
Axonal loss: Especially large axons
Subperineurial edema
No segmental demyelination
Immediate: 100 mg/ml solution; Give 100 mg iv before glucose
Follow-up: 100 mg i.m. for 3 to 5 days
Chronic therapy: 50 mg i.m. for 2 weeks, then, Thiamine 50 mg p.o. per day
Prophylactic: Treat with thiamine before giving i.v. glucose
Response: Oculomotor change best; Dementia & Neuropathy less well
External link: GSU


sample info:

Nitrous oxide (N2O)

Uses: Dental anesthetic
Motor: Related to neuropathy or myelopathy
Pathology: Axonal loss
Source: Gas used in general anesthesia & Dental analgesia
Some patients with associated cobalamin deficiency
Syndromes: Myelopathy or Polyneuropathy
Onset: Delayed; 3 months to 5 years after exposure
Prognosis: Slow, often incomplete recovery
Optic neuropathy
Megaloblastic anemia
Mechanisms: ? Toxicity related to
Inhibition of methionine synthetase in vitamin B12 related pathways
Association: Sickle cell disease

also interesting info on various channels eg potassium, toxins, etc:

User avatar
Volunteer Moderator
Posts: 11170
Joined: Sat Mar 11, 2006 4:00 pm


Return to General Discussion


  • Related topics
    Last post

Who is online

Users browsing this forum: No registered users

Contact us | Terms of Service