High-Dose Cyclophosphamide

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

High-Dose Cyclophosphamide

Postby dignan » Wed Aug 16, 2006 7:33 am

This is a drug they've been using for MS patients for many years, but it is interesting to me that it appears quite effective for some people with severe cases.

High-Dose Cyclophosphamide for Moderate to Severe Refractory Multiple Sclerosis.

Gladstone DE, Zamkoff KW, Krupp L, Peyster R, Sibony P, Christodoulou C, Locher E, Coyle PK.
Author Affiliations: Departments of Medicine, Neurology, Radiology, and Ophthalmology, State University of New York at Stony Brook.
Arch Neurol. 2006 Aug 14;

BACKGROUND: High-dose cyclophosphamide is active in immune-mediated illnesses.

OBJECTIVE: To describe the effects of high-dose cyclophosphamide on severe refractory multiple sclerosis.Design, Setting, and Patients Patients with multiple sclerosis with an Expanded Disability Status Scale (EDSS) score of 3.5 or higher after 2 or more Food and Drug Administration-approved disease-modifying therapy regimens were evaluated.

INTERVENTIONS: Patients received 200 mg/kg of cyclophosphamide over 4 days.

MAIN OUTCOME MEASURES: Patients had brain magnetic resonance imaging and neuro-ophthalmologic evaluations every 6 months and quarterly EDSS and quality-of-life evaluations for 2 years.

RESULTS: Twelve patients were evaluated for clinical response (median follow-up, 15.0 months; follow-up range, 6-24 months). During follow-up, no patients increased their baseline EDSS scores by more than 1.0. Five patients decreased their EDSS scores by 1.0 or more (EDSS score decrease range, 1.0-5.0). No patient had a new lesion on brain magnetic resonance imaging. No patient showed any enhancing lesions. Patients reported improvement in all of the quality-of-life parameters measured. Neurologic improvement involved changes in gait, bladder control, and visual function. Treatment response was seen regardless of the baseline presence or absence of contrast lesion activity. Patient quality-of-life improvement occurred independently of EDSS score changes. In this small group of patients with treatment-refractory multiple sclerosis, high-dose cyclophosphamide was associated with minimal morbidity and improved clinical outcomes.

CONCLUSIONS: High-dose cyclophosphamide treatment in patients with severe refractory multiple sclerosis can result in disease stabilization, improved functionality, and improved quality of life. Further studies are necessary to determine the most appropriate patients for this treatment.

http://www.ncbi.nlm.nih.gov/entrez/quer ... med_docsum
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