I found this particularly interesting since my neurologist said stress played no part in relapses. I have to admit though that reading these Pub Med articles sometimes make me feel like they are written in another language. You think they are proving one point only to state something different at the end. Maybe I should have stayed in college
Relationship between stress and relapse in multiple sclerosis: Part I. Important features.
Brown RF, Tennant CC, Sharrock M, Hodgkinson S, Dunn SM, Pollard JD.
Department of Psychology, University of New England, Armidale, NSW 2351, Australia. firstname.lastname@example.org
OBJECTIVE: The aim of this two-year prospective study was to examine the relationship between multiple aspects of life-event stress and relapse in multiple sclerosis (MS) patients. BACKGROUND: Few studies have defined the critical features of this life-event stress; for example, stressor duration, frequency, severity, disease-dependency, valency, or stressor constructs, such as the propensity to cause emotional distress/threat or the frustration of life goals. METHODS: 101 consecutive participants with MS were recruited from two MS clinics in Sydney, Australia. Stressful life events were assessed at study-entry and at three-monthly intervals for two years. Patient-reported relapses were recorded and corroborated by neurologists or evaluated against accepted relapse criteria. RESULTS: Acute events, but not chronic difficulties (CDs), predicted relapse occurrence: acute stressor frequency counts predicted greater relapse risk, along with low disability score (EDSS) and being male. We also confirmed the bi-directional stress-illness hypothesis: stressors predicted relapse, and relapse separately predicted stressors. CONCLUSIONS: Life-event stress impacts to a small degree on MS relapse. The number and not the severity of acute stressors are most important; chronic stressors do not predict later relapse. Males and those with early stage disease are also at greater risk of relapse. MS patients should be encouraged to reduce acute stressors during times of high stress, and feel reassured that disease-related chronic stressors do not increase their relapse risk.
PMID: 16900759 [PubMed - in process]