Thanks Scooby and Batpere—
I can’t say that I really understand the details of the wonders of this new mouse but on the surface it seems to me that this “new mouse” is still focused on the “auto” immune system and white matter damage. I thought at least some MS research was rapidly moving beyond that.
A sampling of that research:
Etiopathogeny of MS
MT MRI Metrics Predict Accumulation of Disability Eight Years Later in People with MS
However, it appears, on the basis of recent findings, that multiple sclerosis is not only a disease of the immune system but also implies specific neurobiological factors which must be determined in studies to come.
This study also suggests that GM damage is one of the key factors associated with disability accumulation in this 'white matter' condition.
The Contribution of Demyelination to Axonal Loss in MS
These findings suggest that gray matter loss is related to other aspects of brain pathology and has more clinical relevance than white matter atrophy in MS.
Pathology and Definition of MS
Our results indicate that plaque load did not correlate with brain weight. Unexpectedly, after adjusting for sex, age and duration of disease, correlations between total plaque load and axonal loss in both the corticospinal tract and sensory tracts were weak or absent at each level investigated. Since there was little correlation between plaque load and axonal loss, the possibility that demyelination is not the primary determinant of spinal cord axonal loss warrants consideration.
During the relapsing-remitting phase, focal lesions are at the forefront of the pathological abnormalities.
During the progressive phase, be it secondary or primary, macroscopic atrophy and axonal loss, the main explanation of the irreversible neurological disability and the expression of the diffuse, chronic and progressive degeneration of the CNS, are emerging to the first place.
As for autoimmunisation which leads to the selective destruction of myelin, is it primary or secondary to an oligodendrocytic apoptotic process?
Now, we’ve discussed the above question and whether or not MS is “auto-immune” with respect to myelin damage several times. Damage to neurons is another question and here’s one perspective on that sequence.
Neuronal Cell Injury Precedes Brain Atrophy in MS
Enough I know. That's just some of the info I've used to form my opinion they will probably need to find an even better mouse model than the one they described. I hope they get on with it too.