Could LIFNano be the new breakthrough treatment for MS?

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Could LIFNano be the new breakthrough treatment for MS?

Postby MSUK » Mon Jun 05, 2017 4:44 am

LIFNano is a simple and safe technology set to unlock new treatments for a number of neurodegenerative diseases. Founder of the technology, Dr Su Metcalfe believes it could well be the cure for MS we’ve all been waiting for...Read more - http://www.ms-uk.org/could-lifnano-be-new-breakthrough-treatment-ms-050617
MS-UK - http://www.ms-uk.org/
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Re: Could LIFNano be the new breakthrough treatment for MS?

Postby David1949 » Mon Jun 05, 2017 12:06 pm

I don't mean to throw a wet blanket on this but this is a ways out in the future;

"LIFNano has already attracted two major funding awards, from drug firm Merck and the Government’s Innovate UK agency. The company now hopes to attract more investment, with the aim of starting clinical trials in 2020.

Su said: “The 2020 date is ambitious, but with the funding we’ve got and the funding we’re hoping to raise, it should be possible.”"


If they don't start testing until 2020 then when will they be done- 2030?
Someone needs to tell them we don't have that long. Many of us will be dead by then and others will be severely crippled.

Also if big pharma is involved you can bet the price will be through the ceiling. They are not going to put their expensive DMDs out of business so they can sell us a low cost product that actually works.
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Re: Could LIFNano be the new breakthrough treatment for MS?

Postby 1eye » Mon Jun 05, 2017 2:13 pm

That word makes me barf.

I'd like to break through them.

New breakthoughs are probably going to the same place all the old breakthroughs went.
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Re: Could LIFNano be the new breakthrough treatment for MS?

Postby NHE » Tue Jun 06, 2017 2:01 am

Here's a free review article discussing the LIF/IL-6 axis in MS from 2015.

Multiple Sclerosis and the LIF/IL-6 Axis: Use of Nanotechnology
to Harness the Tolerogenic and Reparative Properties of LIF

Nanobiomedicine, 2015, 2:5 | doi: 10.5772/60622

    Leukaemia inhibitory factor (LIF) plays a critical role in "stemness" versus "differentiation", a property that under pins the core value of LIF as a therapeutic for both the treatment of autoimmune disease and for promoting tissue repair. This value can be realized using nano-engineering technology, where a new generation of tools can, with unprecedented ability, manipulate biological functions. One striking example is the treatment of multiple sclerosis (MS). The underpinning biology is the newly identified LIF/IL-6 axis in T lymphocytes, which can tilt the behaviour between immune tolerance versus immune attack. This LIF/IL-6 axis is ideally suited to nanotherapeutic manipulation, given its inherent mechanistic simplicity of two mutually opposing feed-forward loops that determine either tolerogenic (LIF) or inflammatory (IL-6) immunity. Using LIF that is formulated in biodegradable nanoparticles (LIF-NP) and targeted to CD4+ T cells, the axis is harnessed towards immune tolerance. This has implications for the treatment of autoimmune diseases, where the clinical burden is immense. It encompasses more than 100 diseases and, in the USA alone, costs more than $100 billion in direct health care costs annually. Other properties of LIF include the promotion of healthy neuro-glial interactions within the central nervous system (CNS), where, in addition to MS, LIF-NP therapy is relevant to inflammatory neurodegenerative diseases that represent a large and increasing need within aging populations. Thirdly, LIF is a reparative growth factor that can maintain genomic plasticity. LIF-NP supports the use of stem cell-based therapies in regenerative medicine plus augment therapeutic benefits within the patient. These core properties of LIF are greatly amplified in value by the advantage of being formulated as nanoparticles, namely (i) targeted delivery, (ii) exploitation of endogenous regulatory pathways and (iii) creation of surrogate micro-stromal niches. We discuss LIF-NP as a means to harness endogenous pathways for the treatment of MS, both to reset immune self-tolerance and to promote repair of myelin that is required to support health within the nervous system.

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Re: Could LIFNano be the new breakthrough treatment for MS?

Postby NHE » Tue Jun 06, 2017 2:20 am

Here's another recent freely available paper.

Myelin repair in vivo is increased by targeting oligodendrocyte precursor cells with nanoparticles encapsulating leukaemia inhibitory factor (LIF).
Biomaterials. 2015 Jul;56:78-85.

    Multiple sclerosis (MS) is a progressive demyelinating disease of the central nervous system (CNS). Many nerve axons are insulated by a myelin sheath and their demyelination not only prevents saltatory electrical signal conduction along the axons but also removes their metabolic support leading to irreversible neurodegeneration, which currently is untreatable. There is much interest in potential therapeutics that promote remyelination and here we explore use of leukaemia inhibitory factor (LIF), a cytokine known to play a key regulatory role in self-tolerant immunity and recently identified as a pro-myelination factor. In this study, we tested a nanoparticle-based strategy for targeted delivery of LIF to oligodendrocyte precursor cells (OPC) to promote their differentiation into mature oligodendrocytes able to repair myelin. Poly(lactic-co-glycolic acid)-based nanoparticles of ∼120 nm diameter were constructed with LIF as cargo (LIF-NP) with surface antibodies against NG-2 chondroitin sulfate proteoglycan, expressed on OPC. In vitro, NG2-targeted LIF-NP bound to OPCs, activated pSTAT-3 signalling and induced OPC differentiation into mature oligodendrocytes. In vivo, using a model of focal CNS demyelination, we show that NG2-targeted LIF-NP increased myelin repair, both at the level of increased number of myelinated axons, and increased thickness of myelin per axon. Potency was high: a single NP dose delivering picomolar quantities of LIF is sufficient to increase remyelination. Impact statement Nanotherapy-based delivery of leukaemia inhibitory factor (LIF) directly to OPCs proved to be highly potent in promoting myelin repair in vivo: this delivery strategy introduces a novel approach to delivering drugs or biologics targeted to myelin repair in diseases such as MS.

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Note: A pdf can be obtained by clicking on the "Elsevier Open Access" link on the PubMed page.
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