BBB / global disease

bromley · Post by **bromley** » Sat Sep 30, 2006 12:27 am

Dear all,

The UK MS Society recently profiled the work of Prof John Greenwood whose work focuses on the BBB.

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By coincidence, I came across the following research on the BBB.

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It got me thinking about whether MS was a global disease of the CNS rather than a focal disease based on lesions etc. I e-mailed one of my neuros who responded -

You are correct that MS is a generalized disease.

I'm not sure what this means in terms of current / future treatments, but it accords with several other pieces of research that have come out recently i.e that grey matter is affected in addition to white matter. It also begs the question of why more research is not focused on the blood brain barrier / vascular aspects of the disease.

Ian

gwa · Post by **gwa** » Sat Sep 30, 2006 7:03 am

Ian,

The article said that Prof Greenwood had been working on the BBB for 16 years. He is surely not the only scientist tackling this area.

Leaking blood in the brain is pretty creepy to me. I wonder how much blood leaks and where it goes and what the reprocussions are for the MS patient.

Questions, questions and no answers for now.

gwa

bromley · Post by **bromley** » Sat Sep 30, 2006 7:13 am

GWA,

I posted the attached article before, but it shows (illustrates) the BBB.

Ian

http://www.nationalmssociety.org/IMSAug ... nflict.asp