Here’s some info on pregnancy and MS. And yes it seems like Vitamin D3 levels rise in the third trimester and apparently drop post partum, per the following abstract.
Hormonal Changes During Late Pregnancy and Early Postpartum (If you click through there’s a link for free access to the full article.)
We report that during the third trimester pregnancy…..urinary cortisol and norepinephrine excretion and serum levels of 1,25-dihydroxyvitamin were 2- to 3-fold higher than postpartum values.
Logically, a baby is the biggest "foreign body" your own body ever has to accept, so it would make sense that the immune system dies down during the pg, and maybe it bounces back with extra force after the birth.
Besides estriol, progesterone is another hormone that’s high during pregnancy, drops after birth and may be a factor that suppresses the immune system during pregnancy but not after birth, when levels are much lower.
Progesterone Mediated Immunosuppression: Inhibition of K+ Channels
The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive…….
Progesterone effectively blocked a broad spectrum of K+ channels, reducing both Kv1.3
We propose that direct inhibition of K+ channels in T cells by progesterone contributes to progesterone-induced immunosuppression.
So, progesterone seems to block potassium channels, including Kv1.3 as a means of immune suppression. The “other side of the equation” is that some MS research suggests that potassium channel blockade may act to suppress immune mediated neurological diseases.
Potassium Channel Kv1.3 is Highly Expressed in MS Brain
These studies provide further rationale for the use of specific Kv1.3 antagonists in MS.
I find it all fascinating. Seems to me progesterone is a specific Kv1.3 antagonist. Progesterone also acts in the nervous system to provide neuroprotection and support myelination and spinal cord recovery (mice).
(Guys--you have progesterone too. )