Remyelination is extensive in a subset of multiple sclerosis

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Remyelination is extensive in a subset of multiple sclerosis

Postby Thomas » Fri Dec 01, 2006 6:14 pm

Has this been posted already? Just thought it was an interesting study....

Remyelination is extensive in a subset of multiple sclerosis patients

Although spontaneous remyelination does occur in multiple sclerosis lesions, its extent within the global population with this disease is presently unknown. We have systematically analysed the incidence and distribution of completely remyelinated lesions (so-called shadow plaques) or partially remyelinated lesions (shadow plaque areas) in 51 autopsies of patients with different clinical courses and disease durations. The extent of remyelination was variable between cases. In 20% of the patients, the extent of remyelination was extensive with 60-96% of the global lesion area remyelinated. Extensive remyelination was found not only in patients with relapsing multiple sclerosis, but also in a subset of patients with progressive disease. Older age at death and longer disease duration were associated with significantly more remyelinated lesions or lesion areas. No correlation was found between the extent of remyelination and either gender or age at disease onset. These results suggest that the variable and patient-dependent extent of remyelination must be considered in the design of future clinical trials aimed at promoting CNS repair.

http://brain.oxfordjournals.org/cgi/con ... t/awl217v1
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Postby Lyon » Fri Dec 01, 2006 6:52 pm

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Last edited by Lyon on Mon Jun 20, 2011 2:14 pm, edited 1 time in total.
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Postby CureOrBust » Sat Dec 02, 2006 5:47 pm

Lyon wrote:An unsettling thought that just came to me... I'd always wondered how much remyelinating would happen once MS was stopped in it's tracks with the idea that we've no experience with MS being stopped and we might be pleasantly surprised by the amount of remyelinisation the brain can do when it doesn't have to fight to stay ahead of the demyelinsation of MS.

I have been under the impression that one of the things that cause a problem with re-mylination is that the de-mylination process can cause scar tissue. This scar tissue I thought sits where the myelin is suppose to be, is not as good an insulator as myelin and its harder for remylination to occur where it is. Thus, even if you stopped the disease in its tracks, and re-mylination could occur (ie faster than de-mylination), some places would have scar tissue hindering the repairs. ie deficits.
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