I will definitely pass along any info that I think might be of interest.
original quest was to find out how much estrogen an MS patient might need
In terms of my reading, I seriously doubt if anyone knows that and my guess would be that it could vary by individual and age. In the Phase I Estriol Clinical Trial I think they chose the 8 mg estriol dose based on an average of estriol levels in the 6th month of pregnancy (I'm going on memory here which is usually not too great by this late in the evening.)
My basic impression for people with MS based on very small research samples is that it could be the high and low levels of several hormones
that may be problemmatic vs. an absolute amount of any one hormone, including estrogen.
The background statement in this article (about breast cancer risk) could almost mirror what I've read about hormone levels and MS. It's the "excesses and/or deficiences" of several hormones that seem to be associated with various facets of MS and is one of the reasons I personally think people with MS may want to consider balanced
hormone levels. Serum Sex Steroids in Premenopausal Women and Breast Cancer Risk
BACKGROUND: Contrasting etiologic hypotheses about the role of endogenous sex steroids in breast cancer development among premenopausal women implicate ovarian androgen excess and progesterone deficiency, estrogen excess, estrogen and progesterone excess, and both an excess or lack of adrenal androgens (dehydroepiandrosterone [DHEA] or its sulfate [DHEAS]) as risk factors.
As just one example, in MS, I think it was women with both high and low levels of testosterone who had more lesions on MRI.
I was surprised by the Copaxone info myself.
I recently switched from Avonex to Copaxone.
It seems like there is just never quite enough information. Your getting more expert advice definitely seems like the way to go.