You guys are doing a great job here.
I like the emphasis on therapeutics. Usually I post at Braintalk (MGH) -- dignan provides good information there and I see is providing good information here.
I looked through the thread and add a few thoughts and therapies below. Apologies for any errors (and for not providing links and using your format) since I don't have time to do a proper job tonight
Tovaxin, a T-cell vaccination therapy in trials from Opexa Pharmaceuticals. A phase II trial was successful.
Pirfenidone, recently completed a successful trial in SPMS
chrondroitinase, remyelinating monoclonal antibodies, and neuregulins (like glial growth factor-2) in preclinal studies at Acorda Therapeutics. Acorda released the symptomatic therapy 4-AP.
Cellcept (mycophenolate mofetil), heavy-duty immunosuppressant/chemo in various trials
Kineret, (an IL-1 receptor blocker) which had been approved in rheumatoid arthritis. At one time a trial in MS was planned, not sure what came of it.
Low-fat diet with fish oil underwent a succesful trial a couple of years ago (sponsored by the NMSS and Cleveland Clinic). Not sure how this is being followed up though.
Two therapies which should be tested in trials in MS are CoQ10 which proved modestly successful in a large trial in Parkinson's, and the ALS drug, riluzole, which inhibits glutamate excitotocixity and is a sodium channel blocker.
IVIg, which has enjoyed successful trials in RRMS already, is being given another trial in RRMS sponsored by Bayer, probably to gain FDA approval.
Albuterol, an asthma drug, was in a combination trial with Copaxone, but that trial should be complete.
I believe a few other phosphodiesterase type IV inhibitors in addition to Rolipram were being tested in MS like Trental, CDC-801, Mesopram, etc.
Pulse steriods appeared effective in a 5 year trial in MS.
In addition to Zocor, trials are planned (I believe) for Lipitor, another statin drug (which I take
At one time trials were planned for Talampanel (owned by IVAX) but that initiative seems to be dead.
The anti-viral Acyclovir has been in various trials with mixed results.
Again, congratulations and thanks for your site.