Team Project: List of every MS Treatment currently in trials

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

Postby dignan » Wed Aug 18, 2004 12:25 pm

Name of drug/compound: Avandia (rosiglitazone maleate)
Manufacturer: Glaxosmithkline / Schwarz Pharmaceuticals
Location: Chicago
Current FDA Phase: II
Treatment for: MS Progression
Intended for RRMS Sub-types
Mode of Action: Agonist for peroxisome proliferator-activated receptor-gamma, member of hormone receptor family known to affect immune response (already an approved diabetes pill)
Mode of Application: oral
Website for more information: ... #MSongoing (under section titled "Ongoing Trials for Multiple Sclerosis (MS) - Enrollment Closed") ... trials.pdf (page 10)
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Postby Arron » Wed Aug 18, 2004 12:32 pm

dignan, another excellent find!
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Postby dignan » Fri Aug 20, 2004 1:46 pm

Name of drug/compound: CNTO 1275 (monoclonal antibody)
Manufacturer: Centocor
Location: Yale University
Current FDA Phase: I
Treatment for: MS Progression
Intended for RRMS Sub-types
Mode of Action: Blocks IL-12 cytokine activity
Mode of Application: subcutaneous injection
Website for more information: n/a
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Postby Shayk » Sun Aug 22, 2004 7:54 pm

Name of drug: BMS 188667
Manufacturer: ?
Location: Mt. Sinai Medical Center
New York, NY
Dr. Fred Lublin
Curent FDA Phase: Phase II 10 month, double blind placebo controlled.
Treatment: "...blocks activation of a special cell called T cells."
Intended for: RRMS
Mode of Application: IV infusions 1 x mo.
Patient Inclusion Criteria: RRMS, male and female, 18-55 years old, 1 relapse in past 2 years, not on CRABS or pregnant.
Web Site:
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Postby Shayk » Sun Aug 22, 2004 8:09 pm

Name of Drug: Progestin (derviative of the sex hormone progesterone)
Manufacturer: ?? (altho I think many make "progestins")
Location: Enrollment open to patients in European countries where there are centers that participate in the European Database for Multiple Sclerosis.
Current FDA Phase: Progesterones are FDA approved in the US (not for MS though).
Intended for: ?? The last report I read indicated they were "close" to launching a placebo-controlled trial involving 300 post-partum women with MS.
Mode of Action: Progesterone may support myelin.
Mode of Application: Not known for this trial, but in the US progesterone is available orally and as a cream.

Note: I finally got my hormone test results and was surprised to learn that I am not making any progesterone. 8O So, this will be really interesting for me. :)

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Postby xo » Mon Apr 18, 2005 9:10 pm

You guys are doing a great job here. :) I like the emphasis on therapeutics. Usually I post at Braintalk (MGH) -- dignan provides good information there and I see is providing good information here. :)

I looked through the thread and add a few thoughts and therapies below. Apologies for any errors (and for not providing links and using your format) since I don't have time to do a proper job tonight :):

Tovaxin, a T-cell vaccination therapy in trials from Opexa Pharmaceuticals. A phase II trial was successful.

Pirfenidone, recently completed a successful trial in SPMS

chrondroitinase, remyelinating monoclonal antibodies, and neuregulins (like glial growth factor-2) in preclinal studies at Acorda Therapeutics. Acorda released the symptomatic therapy 4-AP.

Cellcept (mycophenolate mofetil), heavy-duty immunosuppressant/chemo in various trials

Kineret, (an IL-1 receptor blocker) which had been approved in rheumatoid arthritis. At one time a trial in MS was planned, not sure what came of it.

Low-fat diet with fish oil underwent a succesful trial a couple of years ago (sponsored by the NMSS and Cleveland Clinic). Not sure how this is being followed up though.

Two therapies which should be tested in trials in MS are CoQ10 which proved modestly successful in a large trial in Parkinson's, and the ALS drug, riluzole, which inhibits glutamate excitotocixity and is a sodium channel blocker.

IVIg, which has enjoyed successful trials in RRMS already, is being given another trial in RRMS sponsored by Bayer, probably to gain FDA approval.

Albuterol, an asthma drug, was in a combination trial with Copaxone, but that trial should be complete.

I believe a few other phosphodiesterase type IV inhibitors in addition to Rolipram were being tested in MS like Trental, CDC-801, Mesopram, etc.

Pulse steriods appeared effective in a 5 year trial in MS.

In addition to Zocor, trials are planned (I believe) for Lipitor, another statin drug (which I take :)).

At one time trials were planned for Talampanel (owned by IVAX) but that initiative seems to be dead.

The anti-viral Acyclovir has been in various trials with mixed results.

Again, congratulations and thanks for your site. :)

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Postby deehammer » Tue Apr 19, 2005 12:05 am

I've got a couple and I hope they aren't repeats, there is so many already, way to go all! :D Okay,
IGIV-C Mount Sinai Medical Center immunomodulating and antiinflammitory for RRMS 12 iv infusions in 1 year phase 2.
OMEGA-Oral megadose Corticosteroid therapy Mount Sinai Medical Center antiinflammitory corticosteroid IV and Oral for all MS acute attacks no phase.

Hope it helps, will keep looking.
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Postby kareng7 » Fri Jul 15, 2005 2:58 pm

Is there any way to turn this fantastic data into a database that we could use to search? Imagine being able to search for all drugs in Phase III trials, or everything that has had positive results in its Phase II study.

Years ago, I created a simple database for a friend's collectibles so I know a teency bit about it, and I'd be happy to help.
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