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Risk assessment for vitamin D

John N Hathcock, Andrew Shao, Reinhold Vieth, and Robert Heaney

ABSTRACT

The objective of this review was to apply the risk assessment methodology
used by the Food and Nutrition Board (FNB) to derive a revised safe Tolerable Upper Intake Level (UL) for vitamin D.

New data continue to emerge regarding the health benefits of vitamin Dbeyond its role in bone. The intakes associated with those benefits suggest a need for levels of supplementation, food fortification, or both that are higher than current levels. A prevailing concern exists, however, regarding the potential for toxicity related to excessive vitaminD intakes. The UL established by the FNB for vitaminD(50 microg, or 2000 IU) is not based on current evidence and is viewed by many as being too restrictive, thus curtailing research, commercial development, and optimization of nutritional policy. Human clinical trial data published subsequent to the establishment of the FNB vitamin D UL published in 1997 support a significantly higher UL.

We present a risk assessment based on relevant, well-designed human
clinical trials of vitamin D. Collectively, the absence of toxicity in trials conducted in healthy adults that used vitamin D dose gt/=250 microg/d (10,000 IU vitamin D3) supports the confident selection of this value as the UL.

Am J Clin Nutr 2007;85:6 –18.

This article is available for reading here.

Cheers
Nick

hey nick i checked it out thru my school library, looks like a goodie.

we should bring it to the attention of these clever girls:
http://www.bmj.com/cgi/content/full/334/suppl_1/s10

according to the mcmaster university home page, this crew of researchers is from there (???) where my ms clinic is also located, at the adjacent hospital. i suppose the evidence based medicine concept is why my ms doc thought i should get on the rebif asap. too bad i was the one who had to bring up vitamin d!