Stem Cells Regenerate Damaged Nerves

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Stem Cells Regenerate Damaged Nerves

Postby gwa » Wed Jan 17, 2007 9:55 am ... ne&storyID

Stem cells nurture damaged spine: study
Wed Jan 17, 2007 10:21 AM ET

BOSTON (Reuters) - Human embryonic stem cells can help regenerate damaged nerves in rats, producing compounds that
nurture nerve cells and stimulate the growth of new ones, Geron Corp. said on Wednesday.

The company's stock rose on the news, published in the journal Stem Cells and Development.

Geron had earlier reported that human embryonic stem cells had helped replace myelin, a fatty covering on nerves that
is vital to function.

Now, the company's researchers said, they had shown the cells produce multiple nerve growth factors, which are proteins
that stimulate the survival and regeneration of neurons.

"In addition to the remyelinating activity as previously reported, GRNOPC1 produces growth factors that can improve the
survival and extension of neuronal circuitry in the spinal cord," said Thomas Okarma, Geron's chief executive.

Shares of Geron rose 48 cents, or 5.5 percent, to $9.13 in Wednesday morning trade on Nasdaq.

Geron is one of several private companies working with human embryonic stem cells, whose use is controversial. Federal
law restricts the use of federal taxpayer money for the research.

Geron has worked to make the embryonic stem cells, which have the power to become any cell or tissue type, develop down
certain lines. Its GRNOPC1 stem cells have started down the road to becoming a type of nerve cell called an oligodendrocyte.

These oligodendroglial progenitor cells produced numerous proteins that stimulate and nourish nerve cells, called neurotrophic
factors, they reported. These included transforming growth factor (beta)1 (TGF-(beta)1), transforming growth factor (beta)2
(TGF-(beta)2), activin A, midkine, vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF).

Each protein plays a different role in helping direct the growth of new cells.

"These factors were all produced at physiologically active levels, and each has been reported to have trophic (nourishing)
effects on neurons associated with the spinal cord," the company said in a statement.
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