Chicken pox virus found in cerebrospinal fluid of PWMS

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Chicken pox virus found in cerebrospinal fluid of PWMS

Postby gwa » Thu Feb 08, 2007 11:12 am ... hl=7&itool

Increased prevalence of varicella zoster virus DNA in cerebrospinal fluid from patients with multiple sclerosis.

* Mancuso R,
* Delbue S,
* Borghi E,
* Pagani E,
* Calvo MG,
* Caputo D,
* Granieri E,
* Ferrante P.

Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation, IRCCS, Milan, Italy.

In order to investigate the possible involvement of viruses in Multiple Sclerosis (MS), the study evaluated
the presence of viral genomic sequences in cerebrospinal fluid (CSF), as markers of viral replication within the
central nervous system (CNS). A total of 85 CSF samples were collected from 38 MS patients, 28 patients with other
neurological diseases and 19 subjects without neurological diseases. Using nested-PCR, the investigation focused
on the presence of human herpes virus DNA, including herpes simplex virus 1 (HSV-1) and 2 (HSV-2), the Epstein-Barr
virus (EBV), varicella zoster virus (VZV), human cytomegalovirus (HCMV), human herpes virus 6 (HHV-6) and JC virus
(JCV). All the CSF samples from the individuals without neurological diseases were negative for viral DNA.
Genomic sequences of HSV-1, HCMV, EBV, HHV6, and JCV were found in patients with MS and other neurological diseases
without significant differences between the two groups. VZV DNA was detected more frequently (P < 0.05) in the MS
group (31.6%), particularly among the relapsing-remitting MS patients (43.5%), compared with patients with other
neurological diseases (10.7%). In addition, the results indicated that JCV and HHV-6 were replicating actively
in the CNS of a small, but significant number of patients with MS and other neurological diseases. Most importantly,
the study revealed a high frequency of VZV DNA in the CSF of patients with MS, suggesting a possible role of this
virus in the pathogenesis of MS.

PMID: 17177306 [PubMed - indexed for MEDLINE]
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Chicken pox virus

Postby gwa » Thu Feb 08, 2007 11:14 am ... 0082_1.htm

Shingles and Chickenpox (Varicella-Zoster Virus)
Varicella-Zoster Virus

Shingles and chickenpox were once considered separate disorders. It is now known that they are both caused by a
single virus of the herpes family known as varicella-zoster virus (VZV). The word herpes is derived from the Greek
word "herpein," which means "to creep," a reference to a characteristic pattern of skin eruptions. VZV is still
referred to by separate terms:

* Varicella: the primary infection that causes chickenpox.
* Herpes zoster: the reactivation of the virus that causes shingles.

Varicella (Chicken Pox). When patients with chickenpox cough or sneeze, they expel tiny droplets that carry the
virus, which in this early form is referred to as varicella virus. If a person who has never had chickenpox or
been vaccinated inhales these particles, the virus enters the lungs. From here it passes into the bloodstream.
When it is carried to the skin it produces the typical rash of chickenpox. ... 0082_1.htm

Herpes Zoster (Shingles).

The virus also travels to nerve cells called dorsal root ganglia. These are bundles of
nerves that transmit sensory information from the skin to the brain. Here, the virus has properties that allow it
to hide from the immune system for years, often for a lifetime. This inactivity is called latency.

If the virus becomes active after being latent, it causes the disorder known as shingles. The virus in this later
form is referred to as herpes zoster. The virus spreads in the ganglion and to the nerves connecting to it. Nerves
most often affected are those in the face or the trunk. The virus, however, can also spread to the spinal cord
and into the bloodstream.

It is not clear why the virus reactivates in some people and not in others. In many cases, the immune system has
become impaired or suppressed from certain conditions such as AIDS or other immunodeficient diseases or from
certain cancers or drugs that suppress the immune system. Aging itself may increase the risk for shingles.
Other Herpes Viruses

The varicella-zoster virus belongs to a group of herpes viruses that includes seven human viruses (it also includes
animal viruses as well). Herpes viruses are similar in shape and size and reproduce within the structure of a cell. The particular cell depends upon the specific virus. The human herpes viruses are:

* Herpes Simplex virus (the most common).
* Varicella-zoster virus (VZV).
* Cytomegalovirus (CMV).
* Epstein-Barre virus (causes mononucleosis).
* Human herpesvirus type 6 (causes roseola).
* Human herpesvirus type 7 (HHV-7).

All herpes viruses share some common properties, including a pattern of active symptoms followed by latent inactive
periods that can last for months, years, or even for a lifetime.
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Postby CureOrBust » Fri Feb 09, 2007 1:48 am

I find myself skim reading the virus articles, because it almost seems like every study finds the virus they are looking for. For ones that compare to healthy individuals, its more prevelant for MS in the CNS. But, again, I cant remember a published study where they say "actually, we didnt find it to be more common in MS" :? So, you could almost say, you name it, we got it (in our CNS...)

Reading my statement above makes me also consider that maybe with our permeable BBB, it just that more pathogens are allowed in. :?
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