I have to admit I was a little surprised to see that there are nine abstracts on Immunocal in Pubmed. It elevates levels of glutathione, which is a good thing in general. Elevating glutathione is the primary reason why alpha-lipoic acid and NAC have been investigated for MS. Here is one of the abstracts.
Effect of supplementation with a cysteine donor on muscular performance.
J Appl Physiol. 1999 Oct;87(4):1381-5.
Lands LC, Grey VL, Smountas AA.
Division of Respiratory Medicine, McGill University Health Centre-Montreal Children's Hospital, Montreal, Quebec, Canada H3H 1P3. firstname.lastname@example.org
Oxidative stress contributes to muscular fatigue. GSH is the major intracellular antioxidant, the biosynthesis of which is dependent on cysteine availability. We hypothesized that supplementation with a whey-based cysteine donor [Immunocal (HMS90)] designed to augment intracellular GSH would enhance performance.
Twenty healthy young adults (10 men, 10 women) were studied presupplementation and 3 mo postsupplementation with either Immunocal (20 g/day) or casein placebo. Muscular performance was assessed by whole leg isokinetic cycle testing, measuring peak power and 30-s work capacity. Lymphocyte GSH was used as a marker of tissue GSH. There were no baseline differences (age, ht, wt, %ideal wt, peak power, 30-s work capacity). Follow-up data on 18 subjects (9 Immunocal, 9 placebo) were analyzed.
Both peak power [13 +/- 3.5 (SE) %, P < 0.02] and 30-s work capacity (13 +/- 3.7%, P < 0.03) increased significantly in the Immunocal group, with no change (2 +/- 9.0 and 1 +/- 9.3%) in the placebo group. Lymphocyte GSH also increased significantly in the Immunocal group (35.5 +/- 11.04%, P < 0.02), with no change in the placebo group (-0.9 +/- 9.6%).
This is the first study to demonstrate that prolonged supplementation with a product designed to augment antioxidant defenses resulted in improved volitional performance.