Phase II High-Dose Cyclophosphamide for Multiple Sclerosis

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Phase II High-Dose Cyclophosphamide for Multiple Sclerosis

Postby Lyon » Fri May 11, 2007 9:05 pm

I can't help digging around in the information regarding "resetting" the immune system. I find it darned interesting. Notice who they are recruiting in this trial....

Inclusion Criteria:

* Diagnosis of secondary progressive (SPMS), primary progressive (PPMS) or progressive relapsing (PRMS) multiple sclerosis
* A diagnosis of MS will be established by fulfilling criteria “Recommended Diagnostic Criteria for Multiple Sclerosis: Guidelines from the Internal Panel on the Diagnosis of Multiple Sclerosis”
* The subtype of MS will be established by the natural history of the disease
* Age >18 but < 75 years
* An extended disability status scale (EDSS) score of >3.5 after two standard treatment regimens IFNB1a IFNB1b Glatiramer acetate Mitoxanthrone Steroids, plasmapheresis or IVIG individually or in combination constitute a single treatment regimen
* Patient must have a left ventricular ejection fraction of > 45%
* Serum Creatinine <3mg/dL
* For women of childbearing potential, serum βHCG (less than seven days before start of cyclophosphamide)
* Willingness to participate in a clinical trial
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