Nick--As I read your post, I kept looking for a way to explain so many recent pediatric cases (youngest was 2 years old, I believe)--so many that 6 pediatric MS clinics are opening around the country.
They haven't had 20-30 years before the time bomb went off. How do they fit into this scenario?
The use of the phrase time bomb by Ashton refers to the majority of those with MS because most PwMS are diagnosed in adulthood. However there are (as you wrote) examples of children being diagnosed (as there are in the case of MS's sibling, type 1 diabetes).
In IDDM there aren't that many GAD proteins that need to be damaged before sypmtoms arise and in my opinion this accounts for this type of diabetes to prvail mostly in children (hence the term juvenile diabetes). Although there are many more brain neurons than there are GAD proteins that need to affected to become noticeable, I would speculate that juvenile MS could arise from a combination of:
*better detection ability of MRI's
*children with very aggressive imune systems[/list]
*repeaded attacks by the immune system on the same part of the brain
*a dominance of causal elements in the envirnment[/list]
*neurologists trying to put idle MRI scanners to use[/list]
Are these children symptomatic or are they only with lesions?