Previous studies have shown that the neuroprotective hormone, testosterone, administered immediately after neural injury, reduces reactive astrogliosis.
In conclusion, testosterone controls reactive gliosis and its metabolites, oestradiol and dihydrotestosterone, may be involved in this hormonal effect. The regulation of gliosis may be part of the neuroprotective mechanism of testosterone.
DHEA significantly increased the area of white matter spared at the epicenter and reduced the area of reactive gliosis surrounding the lesion
These results provide evidence of the anti-apoptotic and anti-astrogliotic effects of progesterone
Purely a stab in the dark, but could the scar tissue be formed to stop the neuron dying by being unprotected? I have herd that myelin may not only serve to increase the electrical speeds, but may also provide nourishment to the nerve. Maybe scarring does this to some extent, better than nothing?TwistedHelix wrote:However, if the scar tissue is there for a reason I haven't thought of, it's possible there might be some negative consequences in preventing it.
...indicate that CHL1 is a glial scar component that restricts posttraumatic axonal growth and remodeling of spinal circuits by homophilic binding mechanisms
Hi Dom,TwistedHelix wrote: "I'm starting to disbelieve everything which used to be "accepted fact" –
So, just because something is thought not to be the case at the moment, it doesn't mean that next week some new evidence won't turn up proving the exact opposite
I hope there are researchers out there who know as much about hormones as you do: it looks to me as if they play a key role in this disease.
Would you agree that the really crucial thing is not the absolute levels of each hormone, but the balance and ratio of them all in relation to each other
recent data showing that fluctuations in hormonal status during the menstrual and estrous cycle can play a determining role in functional outcome in both normal and brain-injured females,
We now know that it is produced in the brain, for the brain, by neurons and glial cells in the central and peripheral nervous system of both male and female individuals.
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