Sammy76 wrote:Apparently Mannitol is in all of the CRAB's and that's what I seem to be allergic to.
Has anyone ever heard allergies to all meds? Do you have any recommendations?
Any help would be appreciated.
Well, it could be that mannitol is used only in the prefilled syringes. I don't know about Rebif or Copaxone, but mannitol is not in the powdered form of Avonex. The ingredients listed for Avonex are 33 µg interferon-ß1a, 16.5 mg albumin human, 6.4 mg sodium chloride, 6.3 mg dibasic sodium phosphate, and 1.3 mg monobasic sodium phosphate, no preservatives. Note that the sodium chloride and dibasic and monobasic sodium phosphates combine to form a buffer solution that's known as phosphate buffered saline or PBS. This buffer is commonly used in laboratories for cell tissue culture. Thus, it's likely that it may be more physiological than the buffers used with the prefilled syringes.
It takes about just an extra minute or so to mix the powdered form and it's really not that much of a hassle. Moreover, many people have noted less side effects with the powdered form of Avonex than with the prefilled syringes. If I remember correctly, Biogen was planning to switch everyone over to the prefilled form but then chose to make both available.
One other benefit of using Avonex is that it's an intramuscular injection so you don't get the injection site reactions that are seen with the other forms of interferon-ß which are injected into subcutaneous tissue.