one for lynda carol

[jimmylegs]

this is all i can get of this item, but it looks interesting, maybe can spark a search for related info

Studies on the development of an insulin resistant rat model by chronic feeding of low magnesium and high sucrose

A et Biotech - jle.com

Decreased insulin sensitivity is recognized as a major metabolic feature of type-2 diabetes and is one of the earliest detectable abnormalities in persons who are prone to develop type-2 diabetes. It is becoming increasingly clear ...

[jimmylegs]

although i am trying to search on the effects of D3 supplementation on magnesium in the bloodstream, i am getting a fair bit of this kind of non-D-related result:

http://www.springerlink.com/content/wr612133677221q9/

Summary Magnesium is an important ion in all living cells being a cofactor of many enzymes, especially those utilising high energy phosphate bounds. The relationship between insulin and magnesium has been recently studied. In particular it has been shown that magnesium plays the role of a second messenger for insulin action; on the other hand, insulin itself has been demonstrated to be an important regulatory factor of intracellular magnesium accumulation. Conditions associated with insulin resistance, such as hypertension or aging, are also associated with low intracellular magnesium contents. In diabetes mellitus, it is suggested that low intracellular magnesium levels result from both increased urinary losses and insulin resistance. The extent to which such a low intracellular magnesium content contributes to the development of macro- and microangiopathy remains to be established. A reduced intracellular magnesium content might contribute to the impaired insulin response and action which occurs in Type 2 (non-insulin-dependent) diabetes mellitus. Chronic magnesium supplementation can contribute to an improvement in both islet Beta-cell response and insulin action in non-insulin-dependent diabetic subjects.

[lyndacarol]

JL--Thanks for this info. On first reading, I am just confused--I must study and read it a few more times. It does seem there is a connection here. My, I wish I were a scientist!