This definitely steers us back towards the, " MS as a vascular disease", theory. Fibrinogen, (a protein involved in blood clotting), has been identified previously as being involved in the MS process and I seem to recall we had some threads on the subject. Also the notion that these clotting proteins shoehorn open the tight junctions between endothelial cells and allow blood products into the brain sounds like a prime candidate for the cause of a leaky blood brain barrier.
Sounds as if good progress has been made toward stopping the harmful effects of these proteins without interfering with the clotting process itself:
http://www.sciencedaily.com/releases/20 ... 105436.htm
Bob, if you gained your Ph.D. on British culture from American television you will be well aware that we all live in country mansions, have a butler, talk like the Queen or the Beatles, and have bowler hats surgically implanted at puberty.
I regret to inform you that this is only true of Ian.