cheerleader wrote:Thanks, rainer.
You saved me an hour of googling
Yeah, I had a feeling Jeff's Schamberg's wasn't "benign." I love how the docs write off anything they don't quite get as benign. I'm sure my husband's MS and Damjan's MS and their blood vessel issues are related. I'm sure the leaky blood vessels have something to do with the spots- and the lesions in their brains and spine.
"Capillaritis is the name given to a harmless skin condition in which there are reddish-brown patches caused by leaky capillaries. It is also known as pigmented purpura"
"PCOs are a variety of flavonoid-like proanthocyanidins found in numerous plants. Some of the most abundant sources are grape seeds and maritime pine bark. Other food sources include hawthorn flowers, various berries, onions, legumes, red wine, and parsley, and related chemicals are found in bilberry. In Europe, PCOs are widely used to treat conditions believed to be related to increased capillary fragility."
Blood-brain barrier (BBB) is the site of regulatory mechanisms which control the exchange of substances between the brain and the blood through the wall of 'true' brain capillaries with tight junctions between endothelial cells. In some pathological situations the permeability of the BBB is increased because of a partial proteolytic degradation of some constituents of the capillary basement lamina. In such cases it is important to restore normal permeability. The effect of procyanidolic oligomers (PCO) on the BBB was investigated in vivo with quantitative morphologic procedures. We also investigated the action of this drug on collagen and basement lamina constituents (Matrigel) in vitro. Collagenase injected in lateral brain ventricles was shown to increase BBB permeability. Per os administration of PCO to rats greatly increased the resistance of brain capillaries to bacterial collagenase, as shown by the inhibition of the diffusion of fluorescein-isothiocyanate-marked dextran particles from the blood-stream into the brain tissues. Calf skin collagen pretreated in vitro with PCO became more resistant to the hydrolytic action of collagenase. Similar, even more intense protective effect was seen when basal lamina constituents containing type IV collagen was incubated with PCO before exposure to pronase. These in vitro effects may partly explain the in vivo protective effect of PCO against the alteration of brain capillaries by i.v. injected bacterial collagenase.
cheerleader wrote:So, I'll see if I can help Jeff get rid of these petechiae with some PCO supplements. Will probably report and follow up on the natural or supplement thread.
TwistedHelix wrote:Just a few wandering thoughts… these marks on the skin really could be a sign of something going on much deeper,
Scattered petechiae and perifollicular purpuric macules were noted on his trunk and lower extremities. After blood drawing, there was a marked increase in the petechiae on his arms distal to the sites of tourniquet placement, with sharp circumferential demarcation... his diet consisted of biscuits, Pop-Tarts, cheese pizza, and water... Serum ascorbic acid level was lower than 5.68 μmol/L (reference range, 11.4-114 μmol/L)... Other nutritional laboratory study results were normal, except for a low zinc level of 8.4 μmol/L (reference range, 9.2-18.4 μmol/L).
The ADAMTS-13 molecule depends upon both zinc and calcium ions for activity...
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