Fruit juices and drug absorbtion

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

Fruit juices and drug absorbtion

Postby Frank » Wed Aug 20, 2008 3:34 am

How do you feel about that? Will it have an impact your diet?
--Frank ... 160050.htm
Treatment: Gilenya since 01/2011, CCSVI both IJV ballooned 09/2010, Tysabri stopped after 24 Infusions and positive JCV antibody test, after LDN, ABX Wheldon Regime for 1 year.
Family Elder
Posts: 543
Joined: Wed Jan 03, 2007 3:00 pm
Location: Germany


Postby VodooDoll » Wed Aug 20, 2008 8:36 am

Thanks for posting this. I knew about the orange & apple juice..not the grapefruit juice.

Very helpful!
User avatar
Family Member
Posts: 30
Joined: Sat Jul 12, 2008 2:00 pm
Location: California

Re: Fruit juices and drug absorbtion

Postby NHE » Wed Aug 20, 2008 10:26 am

Here's a paper relevant to the topic and which may be of interest to MS folks.

Grapefruit juice can increase the plasma concentrations of oral methylprednisolone.
Eur J Clin Pharmacol. 2000 Sep;56(6-7):489-93.

OBJECTIVE: To investigate whether the pharmacokinetics of orally administered methylprednisolone and plasma cortisol concentrations are affected by administration of grapefruit juice. METHODS: In a randomised, two-phase, cross-over study, ten healthy subjects received either 200 ml double-strength grapefruit juice or water three times a day for 2 days. On day 3, 16 mg methylprednisolone was given orally with 200 ml grapefruit juice or water. Additionally, 200 ml grapefruit juice or water was ingested 0.5 h and 1.5 h after methylprednisolone administration. Plasma concentrations of methylprednisolone and cortisol were determined using liquid chromatography/mass spectrometry (LC/MS/MS) over a 47-h period. RESULTS: Grapefruit juice increased the total area under the plasma methylprednisolone concentration-time curve (AUC 0--infinity) by 75% (P < 0.001) and the elimination half-life (t1/2) of methylprednisolone by 35% (P < 0.001). The peak plasma concentration of methylprednisolone (Cmax) was increased by 27% (P < 0.01). Grapefruit juice delayed the time to the Cmax from 2.0 h to 3.0 h (P < 0.05). There was no significant difference in the plasma cortisol concentrations, measured after methylprednisolone administration, between the water and grapefruit juice phases. However, grapefruit juice slightly decreased the morning plasma cortisol concentrations before methylprednisolone administration (P < 0.05). CONCLUSIONS: Grapefruit juice given in high amounts moderately increases the AUC 0--infinity and t1/2 of oral methylprednisolone. The increase in t1/2 suggests that grapefruit juice can affect the systemic methylprednisolone metabolism. The clinical significance of the grapefruit juice-methylprednisolone interaction is small, but in some sensitive subjects high doses of grapefruit juice might enhance the effects of oral methylprednisolone.

User avatar
Volunteer Moderator
Posts: 3718
Joined: Sat Nov 20, 2004 3:00 pm

Postby whyRwehere » Thu Aug 21, 2008 12:29 am

what bothers me about this news, is that the media says juice isn't good for you, when what they should say is: juice isn't good for you, if you are taking medication.
User avatar
Family Elder
Posts: 908
Joined: Mon Oct 03, 2005 2:00 pm

Return to General Discussion


  • Related topics
    Last post

Who is online

Users browsing this forum: No registered users

Contact us | Terms of Service