How so from your perspective?This could go a long way to explaining why MS incidence is rising among women faster than men
Earlier age at menarche increases the risk of MS in women
This effect for the CAR was associated with the onset of menarche alone, unlike cortisol levels over the remainder of the day.
Hypotheses to explain the proposed recent population-level changes in puberty timing from the mid-1900s to the present time are controversial.
One prominent hypothesis is that exposure to endocrine-disrupting chemicals (EDCs) cause an earlier age of puberty.10,20,21
EDCs are a class of chemicals that interfere with steroid hormone activity via a variety of modes of action, at a number of levels, and puberty timing has been identified as a sensitive marker of response to EDC exposure.
In addition to the EDC hypothesis, other hypotheses include increasing obesity11,28,29 and increasing hyperinsulinemia and insulin resistance,30 but all of these hypotheses remain controversial.
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