it's the vascular link i think chris
we recently got onto smoking and vascular issues so i searched smoking and zinc depletion, which turned up the cadmium issue. cadmium in the smoke blocks your body's ability to use zinc, because cadmium and zinc are so similar.
cheer came in to mention that she had run across the cadmium issue related to vascular health but the link to smoking was a surprise.
anyway when you don't have enough zinc the impermeability and integrity of your body's membranes begin to suffer -
blood vessels
http://www.rowett.ac.uk/newsletter/Reso ... ticle4.pdf
In this article, John Beattie describes how dietary zinc intake may influence vascular health and disease. He demonstrates that the development of vascular disease is accelerated in marginal zinc defi ciency and investigates a mechanistic basis for this influence, possibly involving vascular smooth
muscle structural proteins...
http://grande.nal.usda.gov/ibids/index. ... row=361901
Our data indicate that zinc is vital to vascular endothelial cell integrity, possibly by regulating signaling events to inhibit apoptotic cell death.
intestines
Enteric protein loss and intestinal permeability changes in children during acute shigellosis and after recovery: effect of zinc supplementation.
http://gut.bmj.com/cgi/content/abstract/35/12/1707
Intestinal permeability, expressed as a urinary lactulose:mannitol excretion ratio, improved significantly (p = 0.001) along with a significant increase (p = 0.005) in mannitol excretion in the zinc supplemented children, suggesting a resolution of small bowel mucosal damage.
blood brain barrier
http://www.ebmonline.org/cgi/content/full/223/2/175
Zinc Deficiency Exacerbates Loss in Blood-Brain Barrier Integrity Induced by Hyperoxia Measured by Dynamic MRI
However, zinc deficiency resulted in a significant increase in both blood-brain barrier (BBB) permeability (kPS{rho}) and tissue interstitial leakage space (ve), indicating a severely disturbed BBB