Axonal Degeneration & Sodium Density

bromley · Post by **bromley** » Tue Dec 11, 2007 1:31 am

Carolsue,

This will be of interest:

http://www.thisisms.com/ftopict-4717.html

Ian

CureOrBust · Post by **CureOrBust** » Tue Dec 11, 2007 4:59 am

raven wrote:If the 4-AP you are referring to is 4-aminopyridine then I would be cautious. 4-AP is a broad spectrum potassium antagonist which appears to have detrimental effects upon oligodendrocytes and remyelination.....<reference provided>

ARGGGGhhhhhhhh but it can help so much with symptoms. A few months ago when I started 4-AP, someone said they heard that it wasn't good for remylination but did not have a link. Thanks raven.

I have been thinking about it, and I have to say I don't regret using it, as it helped me get through the worst of my disability; even though it may of slowed my improvement. I have been slowly using less (sometimes on purpose and sometimes because i forget the next dose because I don't "need" it). I will now consciously try to use as little as possible.

carolsue · Post by **carolsue** » Tue Dec 11, 2007 11:16 am

thanks bromley!

Muu · Post by **Muu** » Wed Dec 12, 2007 4:11 am

The Lamotrigine trial, that incidentally i happen to be on, is investigating blocking sodium channels and the effect on neurodegenetation. There is a thread in the "Drug Pipeline" forum for anyone interested. It will of course be a cheaper and quicker option if a drug that has already been tested in connection with other conditions- the blood pressure meds or in Lamotrigine's case epilepsy- can be of benefit to ms sufferers. Then, I would imagine, only the efficacy of the drug for treatment of ms needs to be established. The results for the end of the phase 11 trial for Lamotrigine should be available around this time next year. Hopefully yours,
muu