White matter neurons also express a variety of vasoactive molecules, which supports their involvement in the regulation of vascular tone (Okhotin and Kalinichenko, 2003). Specifically, subsets of white matter neurons express nNOS, the enzyme that synthesizes the vasodilatory molecule nitric oxide (Fig. 1D), as well as the vasoconstrictors, NPY (Fig. 1E) and somatostatin (Fig. 1F
jimmylegs wrote:that's weird, it's like most of the ms brains lost a bunch of neurons that help control blood flow... but a few of the patients grew a bunch more new ones??
Axiom wrote:But the trend out of Johns Hopkins seems to be toward following up with ongoing immune modulation. I believe HiCy patients are taking copaxone after ablation now, and there are reports that JH will be comparing copaxone vs tysabri after HiCy soon. I wonder how that will play out?
Of course the JH folks are a lot more knowledgeable than I am, so they must have their reasons, but I certainly recoiled a bit when I saw that they were following up with copaxone; and tysabri after ablation makes me very nervous.
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