The Search for a Cause of MS

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Re: We are all scientists and researchers now!

Postby CureOrBust » Thu Sep 03, 2009 10:28 pm

GiCi wrote:We have a strong positive correlation between MS and defective drainage of blood from the brain and this has been proven in every patient tested.
I find it hard not to believe the CSVI theory's, however, at this stage, I would not wish for ALL other research (and therefore discussions) to simply stop dead in their tracks just yet.

questor wrote:... One theory I've grokked from my reading here is that the immune system is still the entity that causes that damage, not CCSVI per se.
Good to see you understand it is also "just a theory". You may wish to read the following recently published article.

Neuropathological studies of early multiple sclerosis (MS) tissue have shaped prevailing views of the pathogenesis of the disease. The hallmark of the acute MS lesion, inflammatory demyelination, has been largely accepted as evidence of a macrophage-mediated attack on normal myelin, driven by perivascular and parenchymal autoreactive CD4+ Th1 cells primed in the periphery by an unknown self or foreign antigen(s).

Predicated largely upon comparisons with experimental allergic encephalomyelitis, this paradigm has, in recent years, been recognized as a simplification of the events that constitute and perhaps presage lesion formation in the human disease; and the importance of the innate immune cells of the central nervous system, humoral factors, cytotoxic CD8+ T-cells and regulatory T-cells has been emphasized.
Which if I am reading it correctly, implies that the auto-immune basis has been over emphasised, and may not be the source of the main damage.

Funny enough, one of the researchers is my neurologist, and he is far from a CCSVI supporter. :(
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Postby Talisker » Fri Sep 04, 2009 1:51 am

Yeah I don't think it's an auto immune disease, especially one centred around T cells attack the body. Originally scientists though it was caused by circulation problems.

So in my view they should have stuck to there first idea and not been swayed by the EAE.

Because scientist at the end of the day are human and got a tendency to make assumptions fact. ... nergy.html
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Multiple Sclerosis - Looking Beyond Autoimmunity

Postby Quest56 » Tue Oct 13, 2009 10:13 am

Just came across this article on the JRSM website (Journal of the Royal Society of Medicine), calling for the need to focus MS research beyond the autoimmune and EAE models:

Looking Beyond Autoimmunity

I post this here so I can find it again when I have time to read it completely.

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