I can recognize when I am over my head! Please help me understand this:
Antibodies against OspA epitopes of Borrelia burgdorferi cross-react with neural tissue
http://www.sciencedirect.com/science?_o ... 9ebac2011e
Neurological sequela of chronic Lyme disease include
encephalopathy, myelopathy and peripheral neuropathy.
These have generally been attributed to either persistent infection
or pathogen-induced autoimmunity. In this study, we investigated
the presence of cross-reactive human neural epitopes that share
amino acid sequences with Borrelia burgdorferi OspA protein.
Sequence similarity analysis was carried out by searching known
cDNA sequences from brain tissue. The cDNA database search
yielded three sequences that were identical to sequences in OspA.
Corresponding peptides were synthesized and antibodies were
generated against them in rabbits. Antibodies against two of the
homologous OspA peptides were found to react with neurons in
human brain, spinal cord and dorsal root ganglia by