Experimental Drug May Restore Function of Nerves

If it's on your mind and it has to do with multiple sclerosis in any way, post it here.

Experimental Drug May Restore Function of Nerves

Postby scorpion » Fri Nov 20, 2009 1:20 pm

User avatar
scorpion
Family Elder
 
Posts: 1323
Joined: Wed Nov 05, 2008 4:00 pm

Advertisement

Postby sou » Fri Nov 20, 2009 4:47 pm

Hi.

This is your friend again... :-)

What a pity that potassium channel blockers prevent any possible remyelination...

The role of myelin is not just potassium channel covering. It reduces the impedance of the axon by presenting a layer of capacitors around it (the multiple sheaths behave as the foils of a capacitor) and increases the insulation.

When an axon fires, potassium leaves the body and sodium comes in, making it more positive, electrically. Myelin makes this signal travel along the axon requiring fewer "retransmissions" (exchange between sodium and potassium again), thus less time. Then, sodium exits the body and potassium reenters it.

Blocking the potassium channels could make the signal travel a bit further, however it could very well lead into seizures. In addition, blocking the potassium channels throughout the body (not only inside the CNS) could cause problems to the heart and muscles.

Aminopyridine could prove a very useful drug, despite some disappointing results, so far. But remyelination prevention worries me much...

sou
Shortest joke: "We may not be able to cure MS but we can manage its symptoms."
User avatar
sou
Family Elder
 
Posts: 582
Joined: Sat Dec 20, 2008 4:00 pm
Location: Greece


Return to General Discussion

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: Tif