jam, in late '06 i had to go from perth WA to auckland to LA to Toronto, hand out for a few days, and then to rome and finally to bari in the south of italy. i was basically in bed for three days out of my 9 in italy, from the jet lag alone. last time i flew, sept 2009, i noticed that the numbness which usually stays in my hands, was creeping up my arms. then very recently i learned that flying makes your zinc level drop (bizarre). when your zinc goes down suddenly, it may or may not have a similarly sudden effect on your uric acid, but low uric acid levels are associated with relapse. to be on the safe side you could look into checking your zinc level before you leave, and making sure it's optimal (18.2umol/L is the avg in healthy controls). if feasible, you might also like to stage your stops along the way, so that you can get one or two good nights' sleep in on the ground.. i stopped 12 hours in auckland on the way to perth and on the way back - wish i had used them for sleeping, but i went and did the tourist thing instead - VERY SLEEPY TOURIST! especially on the way back, for some reason??