I was going to complain that I was already taking 4 other blood pressure meds and that maybe I did not need another one.
So I checked out the new one HYDRALAZINE. Results was a BIG surprise!!!
Since I am taking the HYDRALAZINE 100 mg THREE TIMES a day I feel that I might well get this "other" unexpected MS reducing benefit.
extract of important part
"Pre-clinical research Multiple sclerosis: Due to its ability to damage myelin nerve sheaths, acrolein may be a factor in the development of multiple sclerosis. Hydralazine, a known scavenger of acrolein, was found to reduce myelin damage and significantly improve behavioral outcomes in a mouse model of multiple sclerosis (experimental autoimmune encephalomyelitis)."
Neuroscience. 2011 Jan 26;173:150-5. Epub 2010 Nov 26.
Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune encephalomyelitis mouse.
Leung G, Sun W, Zheng L, Brookes S, Tully M, Shi R.
SourceDepartment of Basic Medical Sciences, Center for Paralysis Research, Purdue University, West Lafayette, IN 47907, USA.
Oxidative stress is considered a major contributor in the pathology of multiple sclerosis (MS). Acrolein, a highly reactive aldehyde byproduct of lipid peroxidation, is thought to perpetuate oxidative stress. In this study, we aimed to determine the role of acrolein in an animal model of MS, experimental autoimmune encephalomyelitis (EAE) mice. We have demonstrated a significant elevation of acrolein protein adduct levels in EAE mouse spinal cord. Hydralazine, a known acrolein scavenger, significantly improved behavioral outcomes and lessened myelin damage in spinal cord. We postulate that acrolein is an important pathological factor and likely a novel therapeutic target in MS.
© 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
PMID:21081153[PubMed - indexed for MEDLINE] PMCID: PMC3034379[Available on 2012/1/26]
Mol Nutr Food Res. 2011 Sep;55(9):1320-31. doi: 10.1002/mnfr.201100217. Epub 2011 Aug 8.
Acrolein-mediated injury in nervous system trauma and diseases.
Shi R, Rickett T, Sun W.
SourceDepartment of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907-1244, USA.
Acrolein, an α,β-unsaturated aldehyde, is a ubiquitous pollutant that is also produced endogenously through lipid peroxidation. This compound is hundreds of times more reactive than other aldehydes such as 4-hydroxynonenal, is produced at much higher concentrations, and persists in solution for much longer than better known free radicals. It has been implicated in disease states known to involve chronic oxidative stress, particularly spinal cord injury and multiple sclerosis.
Acrolein may overwhelm the anti-oxidative systems of any cell by depleting glutathione reserves, preventing glutathione regeneration, and inactivating protective enzymes.
On the cellular level, acrolein exposure can cause membrane damage, mitochondrial dysfunction, and myelin disruption. Such pathologies can be exacerbated by increased concentrations or duration of exposure, and can occur in normal tissue incubated with injured spinal cord, showing that acrolein can act as a diffusive agent, spreading secondary injury.
Several chemical species are capable of binding and inactivating acrolein. Hydralazine in particular can reduce acrolein concentrations and inhibit acrolein-mediated pathologies in vivo. Acrolein scavenging appears to be a novel effective treatment, which is primed for rapid translation to the clinic.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PMID:21823221[PubMed - in process]