I had been completely symptom/progression/relapse-free for eight years and not taking any disease modifying therapy.
That's great! You're obviously doing something right. I know that stress can wreck havoc on one's system and I'm very sensitive to it. Since moving last year, I'm much happier and my overall health has improved. It's amazing what getting out of a stressful environment can do! I still have the stumbles and some cognitive issues, but they're manageable.
I was never exactly energetic on the prednisone! I just started developing muscles despite not working out and feeling like hell on wheels. It was like PMS 24/7. Husband and dog were thrilled...
I think the burning/itching at the injection site was my biggest complaint on the Copaxone. Benedryl and cortisone were my closest companions. Thankfully, no such reaction with the Rebif. I'll occasionally have some pain and bleeding if a capillary bed gets hit, but it's an infrequent event. I keep a journal and do manual injections, which helps a lot.