Sorry to jump in here but you have definitely confused me further! I’ve been puzzling about this for a while now and agree that your explanation would certainly account for some of the effects I am getting.
The weirdest thing about what is happening to me is that whilst the stiffness increases from just after lunch, it lessens as the afternoon goes on. Thus, by about 8 pm it has virtually gone.
What do you think about splitting the dose? Having experimented with 1, 2, 3 and 4.5 mg, I have now abandoned the 4.5 (way too much stiffness) and gone back to 3 mg. However, I have 30 or so 1 mg left and was wondering what you think about taking a 3 mg at say 11 pm and a 1 mg at 2 pm?
4.5 was seriously too much but 3 mg seems not enough. Dr. Lawrence is looking into getting some 3.8 mg but that may take a while yet. If I tried my suggested split dose, would I need to have a short nap at 2 pm? Does the naltrexone only work when you sleep?
Oh, what I’d give for the answers to all this! BTW, has anyone heard any good reports on the Milk Thistle yet?