Starting Dose (4.5mg)

A board to discuss Low Dose Naltrexone (LDN) as a treatment for Multiple Sclerosis

Starting Dose (4.5mg)

Postby thefireorgan » Thu Apr 26, 2012 10:28 pm

I know it is recommended to start at 3mg or less than work up, but the tablets I ordered only came in 4.5 mg doses and I chose that over the mix-your-own solution for convenience.
I have never really experienced spasticity. I have had considerable stiffness during my last attack. I am not worried about symptoms increasing initially, I will deal with that as it comes.
My question is, will starting straight away at 4.5 mg make the treatment less effective for some reason or is it just jumping on to a rougher ride rather than accelerating up? Anyone out there have good/bad experiences taking this dose. I am male, 22 years old RRMS, main symptoms currently numbness and tingling in hands some "Hug" that comes and goes.
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Re: Starting Dose (4.5mg)

Postby FLJhawk » Fri Apr 27, 2012 7:51 pm

I don't know. The original dose for the FDA-approved application is 50 mg, so you are taking less than a tenth of that.

I have heard someone say it is better to start off at 4.5 mg rather than work your way up, and others say start at 2 mg. Some don't do so well at 4.5 mg but say they do great at 3 mg. Problem with LDN is that a lot of people have opinions, but few (if anyone) really know what the best dosages are.

I don't know how 4.5 mg was derived. Seems that the dosage should be related to weight, and why not 4 mg or 5 mg? I guess a doctor somewhere decided that 4.5 mg was the ideal dosage, but I don't think there were any scientific studies to show what the ideal dosage for MS patients actually is.

If you have 4.5 mg pills, I guess give it a try and see what happens. Let us know. I started off at 2 mg and am working up slowly, getting to 3 mg. No problems so far that I can tell, but some dreams are a bit more vivid and interesting than normal. No nightmares, just wierd things.
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Re: Starting Dose (4.5mg)

Postby Brenda123 » Sat Apr 28, 2012 4:52 pm

I have used LDN for 9 months now, (liquid, I low dose it myself) I am still playing with dosage, I can since its liquid. Anything above 3 ml hasn't worked for me, but we all differ. I believe its trial an error with LDN. I have nothing bad to say about it. I will stick with it, since its been the best for me so far! No C.R.A.B.S for me anymore! I have changed diet an supplements, with the help of my GP. My neruo Dr. does not listen to me so I FIRED HIM, sort of. Liquid LDN can be a bother, but I can figure out what works for me. A lil time an effort goes a long way.

Best of Luck!!!!!!
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Re: Starting Dose (4.5mg)

Postby Kronk » Fri Dec 06, 2013 3:03 pm

I did 3mg for a week before going up to 4.5mg. I didn't notice a difference. I have heard that if you have issues sleeping take it away from bedtime. There was a study done that proved there is no additional efficacy in taking it closer to sleep. I take it immeadiately before sleeping with my Copaxone, and have quality sleep every night but as previous poster said we all differ.
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Re: Starting Dose (4.5mg)

Postby supaguy » Fri Dec 06, 2013 5:37 pm


I have been taking LDN for just under two years.

Why do you think that the few drug trials of LDN have not been a shining success? Did the drug dose meet the needs of the patient or did the patient meet the needs of the drug trials?

What you should have done is order LDN in LIQUID form. One uses a graduated dropper. Start at 1mg and gradually ramp up by 0.5 ml increments over a period of many weeks or even months. You keep increasing, hopfully feeling better and better until you start feeling worse again ... then fall back to the dose where you felt best. When, and only when, you are stable on that established dose do you fork out your hard-earned money on LDN capsules of a fixed dose.

Any help?

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Re: Starting Dose (4.5mg)

Postby LillyMS » Fri Apr 04, 2014 12:36 pm

does usi8ng larger does make LDN less effective? I thought it was other way around? thanks
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Joined: Wed Apr 02, 2014 3:23 pm

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