This Is MS Multiple Sclerosis Community: Knowledge & Support

I know it is recommended to start at 3mg or less than work up, but the tablets I ordered only came in 4.5 mg doses and I chose that over the mix-your-own solution for convenience.
I have never really experienced spasticity. I have had considerable stiffness during my last attack. I am not worried about symptoms increasing initially, I will deal with that as it comes.
My question is, will starting straight away at 4.5 mg make the treatment less effective for some reason or is it just jumping on to a rougher ride rather than accelerating up? Anyone out there have good/bad experiences taking this dose. I am male, 22 years old RRMS, main symptoms currently numbness and tingling in hands some "Hug" that comes and goes.

I don't know. The original dose for the FDA-approved application is 50 mg, so you are taking less than a tenth of that.

I have heard someone say it is better to start off at 4.5 mg rather than work your way up, and others say start at 2 mg. Some don't do so well at 4.5 mg but say they do great at 3 mg. Problem with LDN is that a lot of people have opinions, but few (if anyone) really know what the best dosages are.

I don't know how 4.5 mg was derived. Seems that the dosage should be related to weight, and why not 4 mg or 5 mg? I guess a doctor somewhere decided that 4.5 mg was the ideal dosage, but I don't think there were any scientific studies to show what the ideal dosage for MS patients actually is.

If you have 4.5 mg pills, I guess give it a try and see what happens. Let us know. I started off at 2 mg and am working up slowly, getting to 3 mg. No problems so far that I can tell, but some dreams are a bit more vivid and interesting than normal. No nightmares, just wierd things.

I have used LDN for 9 months now, (liquid, I low dose it myself) I am still playing with dosage, I can since its liquid. Anything above 3 ml hasn't worked for me, but we all differ. I believe its trial an error with LDN. I have nothing bad to say about it. I will stick with it, since its been the best for me so far! No C.R.A.B.S for me anymore! I have changed diet an supplements, with the help of my GP. My neruo Dr. does not listen to me so I FIRED HIM, sort of. Liquid LDN can be a bother, but I can figure out what works for me. A lil time an effort goes a long way.

Best of Luck!!!!!!