BillR wrote :
The simple explanation:
Naltrexone is an FDA approved drug (1984) that was originally intended to treat people suffering from opium (e.g., heroin) addiction. It treated these addictions by blocking the "pleasant" effects from the drug, so addicts who took it did not get "high" anymore.
How does it block the "high?" There are receptors in our brain that an opioid like heroin would use to get into the cell and do its deed. Naltrexone blocks those receptors, so the heroin can't have an effect. Think about it like a puzzle piece-- some brain cells have a piece that accepts opium and its derivatives, and the Naltrexone simply matches that piece. When the heroin floats around, it has no where to go.
OK, that's all well and good, but what relevance is there to Multiple Sclerosis?
Well, those opiod receptors in our brains are not JUST for receiving drugs like heroin-- our bodies actually produce opiods every day, among other things, we produce a set of hormones called endorphins. So if you were to take Naltrexone, you would actually block the reception of something your body produces. These hormones, as it turns out, play a very important part in controlling the immune system. Keep this in mind for what we'll talk about below.
The FDA-approved dosage for heroin addicts was 50 milligrams per day. This ensured that those receptors were blocked all day and there was no chance that any heroin could connect with a cell and give the user a "high."
BUT a medical doctor named Dr. Bihari found that if you give someone a much lower dose, say THREE milligrams instead of 50, you would not block the receptors all day, but just for a couple of hours. After that, everything would function as normal.
But the human body is funny-- when you block something, it often responds by producing more. In other words, if you were to take Naltrexone at a low dose (Low Dose Naltrexone, even!) you would block the receptors for a couple hours. The body would notice that it was not receiving the endorphins it produced, so it would think "Since they're not getting though, I must not be producing enough-- turn it up!" The gland responsible for producing the endorphins, called the pituitary, would respond by producing significantly more. Not enough to cause any problems, but enough to make a difference.
So how can this all matter for Multiple Sclerosis? Remember how we discussed above that the endorphins actually regulate the immune system? Well, in Multiple Sclerosis, the immune system is malfunctioning-- it's attacking it's own body. Anything that helps regulate, control, and tame the immune system could potentially have a positive effect on MS. And that's exactly what some people who take LDN report-- a halt of the progression of the disease, and even some improvement in symptoms.
I wonder, is it true that LDN related to more production of endorphin?
From the book i read, "The Miracle of Endorphin", by dr. Shigeo Haruyama :
Beta-Endorphin is a brain morphine..is a happiness hormones, functions as neurotransmitter n neuromodulator.
Beta-endorphin helps to improve immune system enable our body to fight infections and it helps to improve blood flow by restoring blood vessel condition. This happiness hormones also effective to increase your energy level and reduce pain (analgesic effect). They become active not only in the brain's cells receptors but also in all cells receptor in our body.
How our body can produce endorphin?
1. Eating food which is high in protein n low in calories, amino acids needed to produce these happiness hormones
2. Exercise, strecthing or walking min 5000 steps everyday help to release happiness hormones
3. Meditation, deep breathing could take us into alpha wave state which help to release happiness hormones
4. Accupressure, tapping meridian points in the face could stimulate secretion of happines hormones (just like EFT)
Our body release endorphin when we feel happy, n when we get into stress the opposite hormones is produced which have negative impact to our body.
I hope this information helps you in any way.
All we need is just Laugh Daily Now (LDN)....hohoho