I have been on LDN about 7 months, I started at 3mg and jumped to 4.5mg after a month. I did not notice anything, much like taking a vitamin. I had 9 lesions when diagnosed in 2012 and 5 relapses in the 6 months that followed. I started Copaxone after the 4th and LDN after the 5th. I think i have had 1 relapse since I have been on LDN but it was incredibly minor, 2 of my toes on my left foot fell asleep for a week. My primary existing symptom of poor vision in my right eye was not improved by LDN. I did notice it changed a bit... not necessarily for the better, i got better acuity but the contrast dropped a bit. Due to its lack of side effects and the HUGE amount of beneficial anecdotal evidence I wouldn't go without it!