There seems to be two schools of thought on this particular topic. Dr. Bihari does not feel that there is a need for any such breaks from the daily use of LDN, whereas, Dr. Lawrence feels that there might be some sort of accommodation that might occur. He advocates taking a break about every 10 days or so I think (not sure about the schedule because I have never taken an intentional break, I have missed a dose once or twice and never noticed a difference on those days when I did). I have heard it said that there are those that take a break and those that don't so I spose it is entirely up to you. Good luck.