EBV-infected B-cells? We will have an answer soon

A forum to discuss research on the origins of MS and its development.

EBV-infected B-cells? We will have an answer soon

Postby frodo » Sun Apr 16, 2017 10:44 am

This post is about a clinical trial, but I post it here before it will yield the answer to the new MS model.

Some time ago, MS was considered an autoimmune disease of T-cells. These cells were present in lesions (CD4+ and CD8+) and researchers were putting the blame on them, trying to deplete them to control the disease.

Since anti-CD20 depletion success (Rituxan) scientist now know that B-cells are involved, and in fact, CD8+ T-cells are supposed to be fighting the EBV-infected B-cells. Therefore something to boost.

The new idea of intervention is to inject patients with CD8+ cytotoxic T-cells to kill EBV-infected B-cells. Something similar to Rituxan but without secondary effects.

The clinical trial is still not recruiting, but is worth to follow its course:

Trial to Assess the Safety and Feasibility of Adoptive Cell Therapy With Autologous EBV-specific Cytotoxic T Lymphocytes (CTL) in Patients With a First Clinical Episode Highly Suggestive of Multiple Sclerosis (MS and EBV-CTL)

https://clinicaltrials.gov/ct2/show/NCT ... lls&rank=2
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Re: EBV-infected B-cells? We will have an answer soon

Postby SeanReynolds » Wed Apr 19, 2017 7:34 pm

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