Cross-talk between human glial cells and B cells

A forum to discuss research on the origins of MS and its development.

Cross-talk between human glial cells and B cells

Postby frodo » Sat Jun 17, 2017 7:19 am

Cross-talk between human glial cells and B cells help propagation of CNS-compartmentalized in progressive MS

    Astrocytes supported MS B cell survival (including CD27+ B cells)
    M2c-polarized human microglia appeared cytotoxic to B cells. Activated astrocytes increased CD86 expression on B cell surface.
    Similar results are obtained when B cells were exposed to M1-polarized microglia.
    B cells previously exposed to activated astrocytes increased T cell proliferation.
    Beff (pro-inflammatory effector B cells) down-regulate IL-10 production by microglia/macrophage, and substantially enhance pro-inflammatory cytokines (IL-12, TNF & IL-6)

These results indicate a potential bi-directional interaction between disease-relevant human B cell subsets and astrocytes CNS resident microglia and infiltrating myeloid cells, which may influence the propagation of MS-CNS compartmentalized inflammation associated with disease progression.
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