miRNA dysregulation as the source of the disease

A forum to discuss research on the origins of MS and its development.

miRNA dysregulation as the source of the disease

Postby frodo » Mon Oct 16, 2017 11:28 pm

Micro-RNA (miRNA) has been proposed as a biomarker of axon degeneration, but some authors have proposed that they could be the source of the disease:

Source: https://www.ncbi.nlm.nih.gov/pubmed/28990564

"The etiology of the disease remains unclear but the recent discovery of a dysregulated miRNA network in both cells and extracellular fluids of MS patients has brought new insights on the pathophysiological mechanisms involved in this disorder. miRNAs can induce a T cell polarization towards a pathological Th17 or Th1 phenotype and a deleterious activation of microglia, the CNS-resident macrophages"

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