Diagnostic tests pipeline

A forum to discuss research on the origins of MS and its development.

Diagnostic tests pipeline

Postby frodo » Tue Jun 05, 2018 5:31 am

I am gonna try to maintain here a review about some diagnostic tests that are still not in clinical use. Most of them also will serve in the future to monitor the evolution and response to medications:

Advanced MRI technologies

*DTI: MRI that shows Normal Appearing White Matter
*SWI: Susceptibility weighted Imaging: Shows veins, including the central vein of MS lesions.
*MRN: magnetic resonance neurography: Shows damage in peripheral nervous system.

Other imaging technologies

*PET: Positron emission tomography: Can show activated microglia.

Body Fluid biomarkers

*CSF oligoclonal bands: Currently used in clinical diagnosis
*CSF specific proteins
*MRZ Reaction: Measles Rubeola and Zoster reaction (two positives out of three)
*Light chains (pieces of immunoglobulins) in blood or CSF
*Neurofilament light: [2]
*microRNAs (miRNAs) in blood or CSF: [1][2]
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