This is extremely informative and very much appreciated.
I recently found, among all my info about MS and hormones, information about an "immunity research project" at the University of Missouri-Columbia. The study is entitled Phytoestrogens and the Innate Immunity in ER-Deficient Mice
(ER = estrogen)
The goal of this proposal is to determine the range and mechanism(s) of action of phytoestrogens (genistein, daidzein and soy extracts) on innate immune function via estrogen receptor-dependent and independent pathways.....Our hypothesis is that phytoestrogen signaling via the ER-alpha and/or ER-beta receptors is an important positive regulator of innate macrophage and NK cell function
They proposed to use 2 murine models of bacterial inflammation, mycobacterial which they say is an intracellular pathogen and Helicobacter hepaticus, which is an extracellular pathogen.
Of course, I can't make heads or tails out of this last bit but thought it might mean something to you given your educational background.
Anyway, the basic objectives of the study are to determine the effects of loss of ER alpha, ER beta, and ER alpha and beta signaling on bacterial-induced inflammation.
Now, my question. Since I believe there is emerging information that the ER alpha may be neuroprotective in MS, and since this study leads me to believe there may be "natural", for lack of a better word, sources of this,
a) Is that true? and, if so b) What are some natural sources that contain genistein, daidzein? c) Which sources contain ER-alpha, and d) What might be some of the pros and cons of adding them to one's regimen?
The info I got originally that I'm citing from was from www.phyto-research.org/immunity
Of course, it's also interesting that they're studying "bacterial-induced inflammation" in the immune system, macrophages and NK cell function, but that's for another thread I think.
Thanks for any light you or someone else can shed just on sources of this ER-alpha that might be right around the corner somewhere.